Endocrine Abstracts

: Postmenopausal osteoporosis is a common condition affecting many women. Management of postmenopausal osteoporosis involves the administration of vitamin D, calcium and antiresorptive agents. The long-term management of postmenopausal osteoporosis with antiresorptive agents may present some dangers and adverse effects such as bone necrosis or atypical bone fractures.Case report: The aim was to describe the case of a female patient with postmenopausal ...

Vitamin D deficiency has been observed in diabetes mellitus type 2 patients. It has been found to be related to poor glycemic control in diabetes mellitus type 2 patients as well as in patients with gestational diabetes. The administration of vitamin D in diabetes mellitus type 2 patients with vitamin D deficiency has been found to have conflicting results on blood glucose control. The aim was to assess the effect of vitamin D administration in diabetes mellitus type 2 patient...

Primary hyperparathyroidism is currently recognized with increasing frequency by routine calcium measurement in biochemical examinations. Primary hyperparathyroidism may be due to a parathyroid adenoma, parathyroid hyperplasia and, rarely, parathyroid carcinoma. Cinacalcet is used in the medical management of primary hyperparathyroidism.The aim was to assess the role of cinacalcet in the treatment of primary hyperparathyroidism.Pat...

Although the prognosis of thyroid cancer is in general quite favorable when standard management paradigms are applied, some patients do much less well. Radioactive iodine refractory, recurrent or metastatic disease is prognostically more worrisome. Sorafenib, a multitargeted small molecule kinase inhibitor, including the VEGF receptor and BRAF kinase, has been evaluated in patients with thyroid cancer. The aim of the study was to present a case of metastatic thyroid cancer and...

The management of metastatic differentiated thyroid carcinoma included until recently the use of therapeutic 131I, radiotherapy and in specific cases chemotherapy. However, recently new agents entered in the management of differentiated metastatic thyroid carcinoma which aim at specific cell receptors and inhibit the growth of the carcinoma in a specific and targeted way.The aim was to present the experience of the use of the receptor tyrosine...

Differentiated thyroid carcinoma represents a small percentage of human carcinomas. However, it is the commonest endocrine neoplasm and if diagnosed and treated properly does not affect the long-term survival of the patients.Aim: The aim was to study differentiated thyroid carcinoma affecting young adults.Patients and methods: All patients presenting with thyroid carcinoma to the department from 01.01.2002 to 31.12.2008 were review...

Medullary thyroid carcinoma is an uncommon malignancy of hereditary and sporadic presentation. Mutations in the RET-protooncogene are involved in the pathogenesis of >50% of the sporadic cases. Currently, there is no effective treatment for metastatic medullary thyroid carcinoma. The aim was to present a case of metastatic medullary thyroid carcinoma that was treated by the administration of sorafenib, a multiple kinase inhibitor.A patient, female ag...